ARTICLES BY JOHN ONCEA

• The FDA's RTCT Push: What It Is; Why It Matters

  5/20/2026

  The FDA launched real-time clinical trials with AstraZeneca and Amgen. Here’s what RTCT is, why it matters, and what it actually demands from the clinical research ecosystem.

• Pharma's Digital Transformation: Where It's Really At

  5/18/2026

  Culture is still pharma’s biggest transformation bottleneck – what does it take to move from project thinking to product thinking?

• How AI Is Changing Clinical Trial Design, Not Just Speed

  5/14/2026

  The real AI opportunity in clinical trials isn’t efficiency – it’s simulating better studies before enrollment begins.

• What Is Clinical Trials Day? Why Technology Helps Research Rise

  5/13/2026

  Clinical Trials Day (May 20) recognizes the legacy of evidence-based medicine and the modern workforce that delivers it, increasingly with help from research technology.

• DiMe's Navigator: Why Teams Still Stall On Digital Endpoints

  5/11/2026

  DiMe’s sDHT Adoption Navigator helps clinical teams move from guidance to action, but the real test is whether organizations use it early enough to matter.

• Digital Endpoints Are Ready. Clinical Development Isn't

  5/7/2026

  Regulatory guidance and validation science for digital endpoints are solid. The real barrier is cross-functional execution – and the cost of waiting is compounding.

• Why Clinical Trial Data Cleaning Must Go Continuous (And How To Do It)

  5/4/2026

  Cleaning data is no longer an afterthought; it’s a continuous, risk-based must-have that protects integrity, ensures compliance, and drives reliable results.

• Sites Are Building Their Own Tech – SCRS On What That Means

  4/30/2026

  SCRS’s Jimmy Bechtel on why Bring-Your-Own-Tech is both a protest and a performance differentiator, and what the industry needs to do about it.

• When The System Breaks, Who Pays? SCRS On Site Tech Gaps

  4/27/2026

  SCRS CSSO Jimmy Bechtel on why clinical site tech integration is an architecture problem – and who bears the risk when remote systems fail.

• HTA, Digital Twins, And Building Clinical Tech That Lasts

  4/24/2026

  ISPOR CEO Rob Abbott on HTA-integrated trial design, digital twin evidence gaps, SaMD’s continuous update problem, and the one change he’d mandate for clinical tech.

• Real-World Evidence And Wearables Are Reshaping Trial Tech

  4/22/2026

  ISPOR’s Rob Abbott on why RWE moved to number two in the 2026-2027 HEOR Trends Report, and what wearables, data fragmentation, and HARPER+ mean for clinical platforms.

• HEOR, AI, And The Future Of Clinical Trial Technology

  4/20/2026

  ISPOR CEO Rob Abbott on why HEOR must be in the room when clinical trial tech is built, and what ISPOR’s latest Top 10 HEOR Trends Report means for ClinOps.

• Clinical Research Has System Sprawl Problem

  4/15/2026

  Disconnected systems are strangling clinical trials. Here’s what’s causing the sprawl, why it keeps getting worse, and what needs to change.

• How Clinical Trial Sites Must Adapt To The Predictive Analytics Era

  4/13/2026

  Clinical trial sites are now measured, ranked, and selected by predictive models. Learn how to perform and compete in this data-driven new era.

• Why Patients Drop Out And How To Stop Them

  4/8/2026

  From scheduling friction to silent financial stress, patient dropout derails trials. Here’s what’s causing it and the tech helping sites fight back.

• Predictive Analytics Is Reshaping How Sponsors Run Clinical Trials

  4/6/2026

  Predictive analytics is transforming clinical trial operations, from enrollment forecasting to risk-based monitoring. Here’s what sponsors need to know.

• AI In Clinical Trials: Real Impact, Real Limits, What's Next

  4/2/2026

  Claude’s ClinicalTrials.gov connector changes how sponsors access trial data, but does it change outcomes? A recruitment expert weighs in on impact and what’s still missing.

• AI And Clinical Trial Recruitment: Can It Fix The Funnel?

  3/26/2026

  Anthropic’s ClinicalTrials.gov connector gives Claude real-time access to trial data. But can conversational AI actually improve patient recruitment strategy?

• Edge AI Is Reshaping How Clinical Trials Run

  3/12/2026

  Edge computing and AI are transforming clinical trials – enabling real time monitoring, decentralized research, and faster, more cost-effective drug development.

• Telehealth In Clinical Trials: What Sites And Patients Think

  3/4/2026

  Sites and patients have complicated views on telehealth in trials. Here’s what the evidence shows about who benefits, who bears the burden, and where the limits are.

• Telehealth In Clinical Trials: What You Need To Know

  2/26/2026

  Telehealth is a tool, not a trial design. Learn how televisits, ePRO, and remote monitoring fit into traditional, hybrid, and decentralized clinical trials.

• How Salk And Sabin Helped Create The Modern Clinical Trial

  2/17/2026

  How Jonas Salk and Albert Sabin pioneered double-blind methodology, HeLa cell assays, and IBM data processing – innovations that became the global standard for clinical trials.